FLT3-IN-18 is a highly selective inhibitor of FLT3, exhibiting an IC50 value of 0.003 μM. This compound effectively induces apoptosis and enforces G1 phase cell cycle arrest in FLT3-positive cells. Additionally, FLT3-IN-18 inhibits both FLT3 and STAT5 phosphorylation, making it a valuable tool for investigating the signaling pathways involved in acute myeloid leukemia (AML). Its potency and specificity position FLT3-IN-18 as a crucial reagent for researching FLT3-driven malignancies.
FLT3-IN-18 is a highly selective inhibitor of FLT3, exhibiting an IC50 value of 0.003 μM. This compound effectively induces apoptosis and enforces G1 phase cell cycle arrest in FLT3-positive cells. Additionally, FLT3-IN-18 inhibits both FLT3 and STAT5 phosphorylation, making it a valuable tool for investigating the signaling pathways involved in acute myeloid leukemia (AML). Its potency and specificity position FLT3-IN-18 as a crucial reagent for researching FLT3-driven malignancies.
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