FLT3-IN-23 is a potent inhibitor of the Fms-like tyrosine kinase 3 (FLT3), exhibiting an IC50 value of 7.42 nM. It demonstrates significant antiproliferative activity against BaF3 cells harboring multiple FLT3 tyrosine kinase domain (TKD) and internal tandem duplication (ITD) mutations. This compound serves as a valuable tool for research in targeted therapies for FLT3-mutant leukemias.
FLT3-IN-23 is a potent inhibitor of the Fms-like tyrosine kinase 3 (FLT3), exhibiting an IC50 value of 7.42 nM. It demonstrates significant antiproliferative activity against BaF3 cells harboring multiple FLT3 tyrosine kinase domain (TKD) and internal tandem duplication (ITD) mutations. This compound serves as a valuable tool for research in targeted therapies for FLT3-mutant leukemias.
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