FLT3/ITD-IN-2 is a selective inhibitor of FLT3 internal tandem duplications (FLT3-ITD), exhibiting IC50 values of 0.3 nM for FLT3D835Y, 0.4 nM for FLT3, and 1.0 nM for FLT3-ITD. This compound effectively blocks FLT3 phosphorylation and demonstrates robust antiproliferative effects on acute myeloid leukemia cell lines. It is a valuable tool for research into targeted therapies for leukemia and related disorders.
FLT3/ITD-IN-2 is a selective inhibitor of FLT3 internal tandem duplications (FLT3-ITD), exhibiting IC50 values of 0.3 nM for FLT3D835Y, 0.4 nM for FLT3, and 1.0 nM for FLT3-ITD. This compound effectively blocks FLT3 phosphorylation and demonstrates robust antiproliferative effects on acute myeloid leukemia cell lines. It is a valuable tool for research into targeted therapies for leukemia and related disorders.
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