Foretinib (GSK1363089, XL880)

Foretinib (GSK1363089), a multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces Anoikis, and impairs ovarian cancer metastasis.
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Product Name Price Stock Qty
Foretinib 5mg
Special Price $32.00 Regular Price $40.00
In stock
Foretinib 25mg
Special Price $96.00 Regular Price $120.00
In stock
Foretinib 50mg
Special Price $176.00 Regular Price $220.00
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Foretinib 100mg
Special Price $288.00 Regular Price $360.00
In stock
Foretinib 10mM * 1mL in DMSO
Special Price $56.00 Regular Price $70.00
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Adooq Products cited in reputable paper
Adooq's Foretinib (GSK1363089, XL880) has been cited by 6 publications
  • Ayaka Kojima, .et al. , Xenobiotica, 2022, Jul;52(7):669-675 PMID: 36251932
  • Narges K Gortany, .et al. , Cancer Chemother Pharmacol, 2021, Mar 10 PMID: 33688998
  • Hamzehlou S, .et al. , Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
  • Hayato Ogura, .et al. , Sci Rep, 2017, 7: 5519 PMID: 28717217
  • Fuse MJ, .et al. , Mol Cancer Ther, 2017, Oct;16(10):2130-2143 PMID: 28751539
  • Ryohei Katayama, .et al. , Clin Cancer Res, 2015, Jan 1; 21(1): 166-174 PMID: 25351743
  • Biological Activity
    Discription Foretinib (GSK1363089), a multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces Anoikis, and impairs ovarian cancer metastasis.
    Targets
    Target Value
    Product Information
    Catalog Num A10998
    Formula C34H34F2N4O6
    Molecular Weight 632.7
    CAS Number 849217-64-7
    SMILES COC1=CC2=C(C=CN=C2C=C1OCCCN3CCOCC3)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F
    Synonyms GSK089, EXEL-2880
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 87 mg/mL (137.51 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 15.81 mL 79.03 mL 158.05 mL
    0.5 mM 3.16 mL 15.81 mL 31.61 mL
    1 mM 1.58 mL 7.9 mL 15.81 mL
    5 mM 0.32 mL 1.58 mL 3.16 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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