Forimtamig (RG-6324) is a bispecific antibody designed for T-cell engagement, targeting GPRC5D and CD3. This molecule adopts a 2+1 configuration, incorporating two high-affinity binding sites for GPRC5D and a single site for CD3. It is engineered with a P329G LALA mutation in the Fc domain, which reduces binding to Fcγ receptors and C1q without affecting its interaction with the neonatal Fc receptor. The recommended isotype control for Forimtamig is Human IgG1 kappa. This antibody is pivotal in research focused on modulating immune responses, particularly in the context of cancer immunotherapy.
Forimtamig (RG-6324) is a bispecific antibody designed for T-cell engagement, targeting GPRC5D and CD3. This molecule adopts a 2+1 configuration, incorporating two high-affinity binding sites for GPRC5D and a single site for CD3. It is engineered with a P329G LALA mutation in the Fc domain, which reduces binding to Fcγ receptors and C1q without affecting its interaction with the neonatal Fc receptor. The recommended isotype control for Forimtamig is Human IgG1 kappa. This antibody is pivotal in research focused on modulating immune responses, particularly in the context of cancer immunotherapy.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
Frequently Asked Questions
What are Biosimilar Antibodies?
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research.
Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
