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FLT3 inhibitor

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Catalog No. A14214

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
G-749 5mg A14214-5
G-749 10mg A14214-10
G-749 25mg A14214-25
G-749 10mM * 1mL in DMSO A14214-10mM-D

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

G-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y).


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Chemical Information

Catalog Num A14214
Actions Inhibitor
M. Wt 521.41
Formula C25H25BrN6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1457983-28-6
Synonyms G749

Biological Activity

G-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y).
Target Value
FLT3IC50: 0.4nM
FLT3(D835Y)IC50: 0.6nM
MerIC50: 1nM
AuroraBIC50: 6nM
RETIC50: 9nM
FmsIC50: 19nM
AxlIC50: 20nM
AuroraCIC50: 24nM
FGFR1IC50: 25nM
FGFR3IC50: 30nM
c-KitIC50: 142nM
IGF-1RIC50: >300nM
PDGFRαIC50: >300nM
PDGFRβIC50: >300nM


Solubility (25°C)* In vitro DMSO 24 mg/mL heating (46.02 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.18 mL 95.89 mL 191.79mL
0.5 mM 3.84 mL 19.18 mL 38.36 mL
1 mM 1.92 mL 9.59 mL 19.18 mL
5 mM 0.38 mL 1.92 mL 3.84 mL

*The above data is based on the productmolecular weight 521.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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