G-749

Catalog No.: A14214

FLT3 inhibitor

G-749

G-749 Chemical Structure

CAS NO. 1457983-28-6

G-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y).

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$210.00
25 mg
$470.00
10mM * 1mL in DMSO
$138.00
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Biological Activity

G-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y).
Targets
Target Value
FLT3IC50: 0.4nM
FLT3(D835Y)IC50: 0.6nM
MerIC50: 1nM
AuroraBIC50: 6nM
RETIC50: 9nM
VEGFR1/FLT1IC50: 18nM
FmsIC50: 19nM
AxlIC50: 20nM
AuroraCIC50: 24nM
FGFR1IC50: 25nM
FGFR3IC50: 30nM
VEGFR2/KDRIC50: 39nM
c-KitIC50: 142nM
IGF-1RIC50: >300nM
PDGFRαIC50: >300nM
PDGFRβIC50: >300nM
In vitro DMSO Warmed: 22 mg/mL (42.19 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.18 mL 95.89 mL 191.79 mL
0.5 mM 3.84 mL 19.18 mL 38.36 mL
1 mM 1.92 mL 9.59 mL 19.18 mL
5 mM 0.38 mL 1.92 mL 3.84 mL

*The above data is based on the productmolecular weight 521.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14214
Actions Inhibitor
CAS No. 1457983-28-6
Formula C25H25BrN6O2
M. Wt 521.41
Purity >98%
Synonyms G749
SMILES CN1CCC(CC1)NC2=NC3=C(C(=O)NC=C3Br)C(=N2)NC4=CC=C(C=C4)OC5=CC=CC=C5
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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