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G3-VC-PAB-DMEA-Duocarmycin DM

Catalog No.: A41566
Drug-Linker Conjugates for ADC
G3-VC-PAB-DMEA-Duocarmycin DM is a duocarmycin-based drug-linker conjugate designed for the development of antibody-drug conjugates (ADCs). This linker selectively releases the duocarmycin moiety upon internalization, leading to targeted cytotoxicity against cancer cells. Its applications include enhancing therapeutic efficacy in oncology research by selectively delivering cytotoxic agents to tumor cells.
G3-VC-PAB-DMEA-Duocarmycin DM 2415664-00-3 Drug-Linker Conjugates for ADC
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionG3-VC-PAB-DMEA-Duocarmycin DM is a duocarmycin-based drug-linker conjugate designed for the development of antibody-drug conjugates (ADCs). This linker selectively releases the duocarmycin moiety upon internalization, leading to targeted cytotoxicity against cancer cells. Its applications include enhancing therapeutic efficacy in oncology research by selectively delivering cytotoxic agents to tumor cells.
Product Information
Catalog NumA41566
FormulaC56H72ClN13O12
Molecular Weight1154.70
CAS Number2415664-00-3
SMILESClC[C@H]1C2=C(C=C(C3=CC=CC=C32)OC(N(C)CCN(C)C(OCC4=CC=C(C=C4)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CNC(CNC(CN)=O)=O)=O)=O)=O)=O)=O)N(C1)C(C5=CC6=CC(OCCN(C)C)=CC=C6N5)=O
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC