GDC-0152

Catalog No.: A14135

IAP antagonist

GDC-0152 Chemical Structure

CAS NO. 873652-48-3

GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity.

Availability: In stock

Package Price Qty
10 mg
$150.00
25 mg
$300.00
50 mg
$500.00
10mM * 1mL in DMSO
$135.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity.
Targets
Target Value
MLXBIR3SGki: 14nM
cIAP1-BIR3ki: 17nM
XIAP-BIR3ki: 28nM
cIAP2-BIR3ki: 43nM
XIAP-BIR2ki: 112nM
cIAP2-BIR2ki: 9.6μM
cIAP1-BIR2ki: 14.5μM
In vitro (25°C) DMSO 99 mg/mL (198.54 mM)
Water 3 mg/mL (6.01 mM)
Ethanol 99 mg/mL (198.54 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.05 mL 100.27 mL 200.55 mL
0.5 mM 4.01 mL 20.05 mL 40.11 mL
1 mM 2.01 mL 10.03 mL 20.05 mL
5 mM 0.4 mL 2.01 mL 4.01 mL

*The above data is based on the productmolecular weight 498.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14135
Actions Antagonist
M. Wt 498.64
Formula C25H34N6O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 873652-48-3
Synonyms GDC0152, GDC 0152
SMILES CC(C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC3=C(N=NS3)C4=CC=CC=C4)NC

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