Biological Activity
GNF 2 is a Bcr-abl inhibitor that inhibits proliferation and induces apoptosis in Bcr-abl-expressing cells.
Targets
Bcr-Abl (SUP-B15 cell line) | Bcr-Abl (K562 cell line) | |||
268 nM | 273 nM |
In vitro | DMSO | 74 mg/mL (197.69 mM) | |
Water | <1 mg/mL (<1 mM) | ||
Ethanol | <1 mg/mL (<1 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 26.72 mL | 133.58 mL | 267.17 mL |
0.5 mM | 5.34 mL | 26.72 mL | 53.43 mL |
1 mM | 2.67 mL | 13.36 mL | 26.72 mL |
5 mM | 0.53 mL | 2.67 mL | 5.34 mL |
*The above data is based on the productmolecular weight 374.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11439 |
---|---|
Actions | Inhibitor |
M. Wt | 374.3 |
Formula | C18H13F3N4O2 |
Solubility | DMSO |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 778270-11-4 |
Synonyms | GNF2,GNF-2 |
SMILES | C1=CC(=CC(=C1)C(=O)N)C2=CC(=NC=N2)NC3=CC=C(C=C3)OC(F)(F)F |
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