GPi688 is a potent and orally active inhibitor of glycogen phosphorylase (GPa), demonstrating IC50 values of 19 nM, 61 nM, and 12 nM for human liver GPa, rat liver GPa, and human skeletal muscle GPa, respectively. This compound effectively inhibits glucagon-mediated glucose output in rat primary hepatocytes. GPi688 is a valuable tool for investigating glucagon-mediated hyperglycemia and related metabolic disorders in research applications.
GPi688 is a potent and orally active inhibitor of glycogen phosphorylase (GPa), demonstrating IC50 values of 19 nM, 61 nM, and 12 nM for human liver GPa, rat liver GPa, and human skeletal muscle GPa, respectively. This compound effectively inhibits glucagon-mediated glucose output in rat primary hepatocytes. GPi688 is a valuable tool for investigating glucagon-mediated hyperglycemia and related metabolic disorders in research applications.
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