GS-9973 (Entospletinib)

Catalog No.: A13884

Syk inhibitor

GS-9973 (Entospletinib) Chemical Structure

CAS NO. 1229208-44-9

GS-9973 is an oral inhibitor of spleen tyrosine kinase (Syk), with potential antineoplastic activity.

Availability: In stock

Package Price Qty
10 mg
$100.00
25 mg
$200.00
50 mg
$260.00
100 mg
$440.00
10mM * 1mL in DMSO
$75.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

GS-9973 is an oral inhibitor of spleen tyrosine kinase (Syk), with potential antineoplastic activity.
Targets
Syk (Cell-free assay)
7.7 nM
In vitro DMSO 82 mg/mL heating (199.29 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.3 mL 121.52 mL 243.04 mL
0.5 mM 4.86 mL 24.3 mL 48.61 mL
1 mM 2.43 mL 12.15 mL 24.3 mL
5 mM 0.49 mL 2.43 mL 4.86 mL

*The above data is based on the productmolecular weight 411.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13884
Actions Inhibitor
M. Wt 411.46
Formula C23H21N7O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1229208-44-9
Synonyms GS9973, GS 9973, Entospletinib
SMILES C1COCCN1C2=CC=C(C=C2)NC3=NC(=CN4C3=NC=C4)C5=CC6=C(C=C5)C=NN6

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