GS-9973 (Entospletinib)

Catalog No.: A13884

Syk inhibitor

GS-9973 (Entospletinib)

GS-9973 (Entospletinib) Chemical Structure

CAS NO. 1229208-44-9

GS-9973 is an oral inhibitor of spleen tyrosine kinase (Syk), with potential antineoplastic activity.

Availability: In stock

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10 mg
25 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Biological Activity

GS-9973 is an oral inhibitor of spleen tyrosine kinase (Syk), with potential antineoplastic activity.
Syk (Cell-free assay)
7.7 nM
In vitro (25°C) DMSO Warmed: 26 mg/mL (63.18 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+30% PEG 300+5% Tween 80+ddH2O 2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.3 mL 121.52 mL 243.04 mL
0.5 mM 4.86 mL 24.3 mL 48.61 mL
1 mM 2.43 mL 12.15 mL 24.3 mL
5 mM 0.49 mL 2.43 mL 4.86 mL

*The above data is based on the productmolecular weight 411.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13884
Actions Inhibitor
CAS No. 1229208-44-9
Formula C23H21N7O
M. Wt 411.46
Purity >98%
Synonyms GS9973, GS 9973, Entospletinib

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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