GSK143 is a highly selective inhibitor of spleen tyrosine kinase (SYK) with an oral bioavailability and a pIC50 of 7.5. It effectively inhibits phosphorylated Erk (pErk) with a pIC50 of 7.1. GSK143 demonstrates significant anti-inflammatory properties and has been shown to reduce immune cell recruitment in the intestinal muscularis in murine models, making it a valuable tool for research in inflammatory diseases and immune response modulation.
GSK143 is a highly selective inhibitor of spleen tyrosine kinase (SYK) with an oral bioavailability and a pIC50 of 7.5. It effectively inhibits phosphorylated Erk (pErk) with a pIC50 of 7.1. GSK143 demonstrates significant anti-inflammatory properties and has been shown to reduce immune cell recruitment in the intestinal muscularis in murine models, making it a valuable tool for research in inflammatory diseases and immune response modulation.
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