GSK2646264 is a potent and selective inhibitor of spleen tyrosine kinase (SYK), exhibiting a pIC50 value of 7.1. This compound also shows inhibitory activity against several other kinases, including LCK, LRRK2, GSK3β, JAK2, VEGFR2, and Aurora kinases, with varying pIC50 values. Due to its ability to penetrate the epidermis and dermis, GSK2646264 is potentially valuable for research applications in dermatological conditions and immune responses.
GSK2646264 is a potent and selective inhibitor of spleen tyrosine kinase (SYK), exhibiting a pIC50 value of 7.1. This compound also shows inhibitory activity against several other kinases, including LCK, LRRK2, GSK3β, JAK2, VEGFR2, and Aurora kinases, with varying pIC50 values. Due to its ability to penetrate the epidermis and dermis, GSK2646264 is potentially valuable for research applications in dermatological conditions and immune responses.
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