GSK481

Catalog No.: A12615

RIP1 inhibitor

GSK481

GSK481 Chemical Structure

CAS NO. 1622849-58-4

GSK481 is a novel benzoxazepinone (BOAz) series of RIP1 inhibitors. Receptor Interacting Protein Kinase 1 (RIP1) has been implicated as a key contributor to inflammation through the regulation of programmed necrosis. Inhibition of this kinase has been shown to hinder cell necrotic death, thereby establishing RIP1 as a viable target for the potential treatment of multiple inflammatory diseases.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $100.00

Special Price $80.00

10 mg

Regular Price: $150.00

Special Price $120.00

25 mg

Regular Price: $280.00

Special Price $224.00

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Biological Activity

GSK481 is a novel benzoxazepinone (BOAz) series of RIP1 inhibitors. Receptor Interacting Protein Kinase 1 (RIP1) has been implicated as a key contributor to inflammation through the regulation of programmed necrosis. Inhibition of this kinase has been shown to hinder cell necrotic death, thereby establishing RIP1 as a viable target for the potential treatment of multiple inflammatory diseases.
Targets
RIP1
In vitro DMSO 70 mg/mL (185.48 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.5 mL 132.49 mL 264.98 mL
0.5 mM 5.3 mL 26.5 mL 53 mL
1 mM 2.65 mL 13.25 mL 26.5 mL
5 mM 0.53 mL 2.65 mL 5.3 mL

*The above data is based on the productmolecular weight 377.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12615
Actions Inhibitor
CAS No. 1622849-58-4
Formula C21H19N3O4
M. Wt 377.39
Purity >98%
Synonyms GSK 481, GSK-481
SMILES O=C(C1=NOC(CC2=CC=CC=C2)=C1)N[[email protected]]3COC4=CC=CC=C4N(C)C3=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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