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Publications citing Adooq Products
Chemical Information
| Catalog Num | A12615 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 377.39 |
| Formula | C21H19N3O4 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1622849-58-4 |
| Synonyms | GSK 481, GSK-481 |
| SMILES | O=C(C1=NOC(CC2=CC=CC=C2)=C1)N[[email protected]]3COC4=CC=CC=C4N(C)C3=O |
Description |
GSK481 is a novel benzoxazepinone (BOAz) series of RIP1 inhibitors. Receptor Interacting Protein Kinase 1 (RIP1) has been implicated as a key contributor to inflammation through the regulation of programmed necrosis. Inhibition of this kinase has been shown to hinder cell necrotic death, thereby establishing RIP1 as a viable target for the potential treatment of multiple inflammatory diseases. | ||||||||||
Targets |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.5 mL | 132.49 mL | 264.98mL |
| 0.5 mM | 5.3 mL | 26.5 mL | 53 mL |
| 1 mM | 2.65 mL | 13.25 mL | 26.5 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.3 mL |
*The above data is based on the productmolecular weight 377.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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