GSK481

Catalog No.: A12615

RIP1 inhibitor

GSK481 Chemical Structure

CAS NO. 1622849-58-4

GSK481 is a novel benzoxazepinone (BOAz) series of RIP1 inhibitors. Receptor Interacting Protein Kinase 1 (RIP1) has been implicated as a key contributor to inflammation through the regulation of programmed necrosis. Inhibition of this kinase has been shown to hinder cell necrotic death, thereby establishing RIP1 as a viable target for the potential treatment of multiple inflammatory diseases.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $100.00

Special Price $80.00

10 mg

Regular Price: $150.00

Special Price $120.00

25 mg

Regular Price: $280.00

Special Price $224.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

GSK481 is a novel benzoxazepinone (BOAz) series of RIP1 inhibitors. Receptor Interacting Protein Kinase 1 (RIP1) has been implicated as a key contributor to inflammation through the regulation of programmed necrosis. Inhibition of this kinase has been shown to hinder cell necrotic death, thereby establishing RIP1 as a viable target for the potential treatment of multiple inflammatory diseases.
Targets
RIP1
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.5 mL 132.49 mL 264.98 mL
0.5 mM 5.3 mL 26.5 mL 53 mL
1 mM 2.65 mL 13.25 mL 26.5 mL
5 mM 0.53 mL 2.65 mL 5.3 mL

*The above data is based on the productmolecular weight 377.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12615
Actions Inhibitor
M. Wt 377.39
Formula C21H19N3O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1622849-58-4
Synonyms GSK 481, GSK-481
SMILES O=C(C1=NOC(CC2=CC=CC=C2)=C1)N[[email protected]]3COC4=CC=CC=C4N(C)C3=O

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