GZD824 Dimesylate

Catalog No.: A15849

Bcr-Abl Inhibitor

GZD824 Dimesylate

GZD824 Dimesylate Chemical Structure

CAS NO. 1421783-64-3

GZD824 is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$150.00
25 mg
$280.00
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Biological Activity

GZD824 is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.
Targets
Target Value
Abl(Q252H)IC50: 0.15nM
Abl(E255K)IC50: 0.27nM
Abl(M351T)IC50: 0.29nM
AblIC50: 0.34nM
Abl(H396P)IC50: 0.35nM
Abl(Y253F)IC50: 0.35nM
Abl(T315I)IC50: 0.68nM
Abl(G250E)IC50: 0.71nM
In vitro (25°C) DMSO 93 mg/mL (128.31 mM)
Water 93 mg/mL (128.31 mM)
Ethanol Insoluble
In vivo Saline 19 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.8 mL 68.99 mL 137.97 mL
0.5 mM 2.76 mL 13.8 mL 27.59 mL
1 mM 1.38 mL 6.9 mL 13.8 mL
5 mM 0.28 mL 1.38 mL 2.76 mL

*The above data is based on the productmolecular weight 724.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15849
Actions Inhibitor
CAS No. 1421783-64-3
Formula C29H27F3N6O.2CH4O3S
M. Wt 724.77
Purity >98%
Synonyms GZD-824 Dimesylate
SMILES CC1=CC=C(C(NC2=CC=C(CN3CCN(C)CC3)C(C(F)(F)F)=C2)=O)C=C1C#CC4=CN=C5C(C=NN5)=C4.CS(=O)(O)=O.CS(=O)(O)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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