GZD824 Dimesylate

Catalog No.: A15849

Bcr-Abl Inhibitor

GZD824 Dimesylate

GZD824 Dimesylate Chemical Structure

CAS NO. 1421783-64-3

GZD824 is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$150.00
25 mg
$280.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

GZD824 is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.
Targets
Target Value
Abl(Q252H)IC50: 0.15nM
Abl(E255K)IC50: 0.27nM
Abl(M351T)IC50: 0.29nM
AblIC50: 0.34nM
Abl(H396P)IC50: 0.35nM
Abl(Y253F)IC50: 0.35nM
Abl(T315I)IC50: 0.68nM
Abl(G250E)IC50: 0.71nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.8 mL 68.99 mL 137.97 mL
0.5 mM 2.76 mL 13.8 mL 27.59 mL
1 mM 1.38 mL 6.9 mL 13.8 mL
5 mM 0.28 mL 1.38 mL 2.76 mL

*The above data is based on the productmolecular weight 724.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A15849
Actions Inhibitor
M. Wt 724.77
Formula C29H27F3N6O.2CH4O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1421783-64-3
Synonyms GZD-824 Dimesylate
SMILES CC1=CC=C(C(NC2=CC=C(CN3CCN(C)CC3)C(C(F)(F)F)=C2)=O)C=C1C#CC4=CN=C5C(C=NN5)=C4.CS(=O)(O)=O.CS(=O)(O)=O

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