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GZD824 Dimesylate

Bcr-Abl Inhibitor

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Catalog No. A15849

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GZD824 5mg A15849-5
$90.00
GZD824 10mg A15849-10
$150.00
GZD824 25mg A15849-25
$280.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GZD824 is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.

GZD824 Dimesylate

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Chemical Information

Catalog Num A15849
Actions Inhibitor
M. Wt 724.77
Formula C29H27F3N6O.2CH4O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1421783-64-3
Synonyms GZD-824 Dimesylate
SMILES CC1=CC=C(C(NC2=CC=C(CN3CCN(C)CC3)C(C(F)(F)F)=C2)=O)C=C1C#CC4=CN=C5C(C=NN5)=C4.CS(=O)(O)=O.CS(=O)(O)=O

Biological Activity

Description
GZD824 is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.
Targets
Target Value
Abl(Q252H)IC50: 0.15nM
Abl(E255K)IC50: 0.27nM
Abl(M351T)IC50: 0.29nM
AblIC50: 0.34nM
Abl(H396P)IC50: 0.35nM
Abl(Y253F)IC50: 0.35nM
Abl(T315I)IC50: 0.68nM
Abl(G250E)IC50: 0.71nM

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.8 mL 68.99 mL 137.97mL
0.5 mM 2.76 mL 13.8 mL 27.59 mL
1 mM 1.38 mL 6.9 mL 13.8 mL
5 mM 0.28 mL 1.38 mL 2.76 mL

*The above data is based on the productmolecular weight 724.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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