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Biological Activity
HA14-1 interacts with Bcl-2 and inhibits the antiapoptotic effect of Bcl-2.
Targets
Bcl-2 | ||||
9 μM |
In vitro (25°C) | DMSO | 80 mg/mL (195.48 mM) | |
Water | Insoluble | ||
Ethanol | 80 mg/mL (195.48 mM) | ||
In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 24.44 mL | 122.19 mL | 244.38 mL |
0.5 mM | 4.89 mL | 24.44 mL | 48.88 mL |
1 mM | 2.44 mL | 12.22 mL | 24.44 mL |
5 mM | 0.49 mL | 2.44 mL | 4.89 mL |
*The above data is based on the productmolecular weight 409.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11448 |
---|---|
Actions | Inhibitor |
CAS No. | 65673-63-4 |
Formula | C17H17BrN2O5 |
M. Wt | 409.2 |
Purity | >98% |
SMILES | CCOC(=O)C1=C(OC2=C(C1C(C#N)C(=O)OCC)C=C(C=C2)Br)N |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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