HIF-1α-IN-5 is a potent inhibitor of HIF-1α, exhibiting an IC50 of 24 nM in HEK293T cells. It also demonstrates inhibitory activity against MAO-A, contributing to its physiological effects. HIF-1α-IN-5 is effective in downregulating mRNA expressions of VEGF and PDK1 under hypoxic conditions, making it a valuable tool for cancer research. Its ability to modulate hypoxia-related pathways provides insights into tumor biology and potential therapeutic strategies.
HIF-1α-IN-5 is a potent inhibitor of HIF-1α, exhibiting an IC50 of 24 nM in HEK293T cells. It also demonstrates inhibitory activity against MAO-A, contributing to its physiological effects. HIF-1α-IN-5 is effective in downregulating mRNA expressions of VEGF and PDK1 under hypoxic conditions, making it a valuable tool for cancer research. Its ability to modulate hypoxia-related pathways provides insights into tumor biology and potential therapeutic strategies.
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