HIF-2α-IN-9 is a selective inhibitor of HIF-2α, effectively modulating hypoxia-responsive pathways. This compound demonstrates significant inhibition of VEGF-A with an IC50 value of 305 nM, influencing tumor growth and angiogenesis. HIF-2α-IN-9 also promotes reactivation of macrophage-mediated tumor immunity, making it a valuable tool for research in cancer biology and therapeutic approaches targeting tumor microenvironments.
HIF-2α-IN-9 is a selective inhibitor of HIF-2α, effectively modulating hypoxia-responsive pathways. This compound demonstrates significant inhibition of VEGF-A with an IC50 value of 305 nM, influencing tumor growth and angiogenesis. HIF-2α-IN-9 also promotes reactivation of macrophage-mediated tumor immunity, making it a valuable tool for research in cancer biology and therapeutic approaches targeting tumor microenvironments.
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