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Biological Activity
Homocarbonyltopsentin (PK4C9) is a small-molecule TSL2-binding compound, binds to pentaloop conformations of TSL2 and promotes a shift to triloop conformations that display enhanced SMN2 exon 7 (E7) splicing with EC50 value of 16 μM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27 mL | 135 mL | 270.01 mL |
| 0.5 mM | 5.4 mL | 27 mL | 54 mL |
| 1 mM | 2.7 mL | 13.5 mL | 27 mL |
| 5 mM | 0.54 mL | 2.7 mL | 5.4 mL |
*The above data is based on the productmolecular weight 370.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18702 |
|---|---|
| CAS No. | 172286-77-0 |
| Formula | C21H14N4O3 |
| M. Wt | 370.36 |
| Purity | >98% |
| SMILES | O=C(C1=NC=C(C(C2=CNC3=C2C=CC=C3)=O)N1)C4=CNC5=C4C=CC(O)=C5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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