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HS-(CH2)3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S-(CH2)5-CO-DM

Catalog No.: A41494
Drug-Linker Conjugates for ADC
HS-(CH2)3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S-(CH2)5-CO-DM is a peptide-cleavable drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. The maytansinoid moiety (DM) enhances cytotoxicity, making this conjugate an effective tool for targeted cancer therapy. Its unique chemical structure allows for precise release of the therapeutic agent in the tumor microenvironment, facilitating specific delivery and reduced systemic toxicity. This reagent is suitable for research focusing on ADC development and optimization.
HS-(CH2)3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S-(CH2)5-CO-DM 2243689-64-5 Drug-Linker Conjugates for ADC
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionHS-(CH2)3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S-(CH2)5-CO-DM is a peptide-cleavable drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. The maytansinoid moiety (DM) enhances cytotoxicity, making this conjugate an effective tool for targeted cancer therapy. Its unique chemical structure allows for precise release of the therapeutic agent in the tumor microenvironment, facilitating specific delivery and reduced systemic toxicity. This reagent is suitable for research focusing on ADC development and optimization.
Product Information
Catalog NumA41494
FormulaC52H78ClN7O14S2
Molecular Weight1124.80
CAS Number2243689-64-5
SMILESC[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(CCCCCSCNC([C@H](C)NC([C@@H](C)NC([C@H](C)NC(CCCS)=O)=O)=O)=O)=O)=O)=O)C)=C(C(OC)=C4)Cl)\C)OC)(NC(O3)=O)O)C)([H])O1
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC