IACS-9439

Catalog No.: A34617
CSF1R Inhibitor
IACS-9439 is a potent and selective inhibitor of the colony-stimulating factor 1 receptor (CSF1R) with a Ki value of 1 nM. This orally active compound demonstrates significant potential in cancer research, particularly for the treatment of advanced solid tumors. It enables investigation into the role of CSF1R in tumor microenvironments and immune modulation.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionIACS-9439 is a potent and selective inhibitor of the colony-stimulating factor 1 receptor (CSF1R) with a Ki value of 1 nM. This orally active compound demonstrates significant potential in cancer research, particularly for the treatment of advanced solid tumors. It enables investigation into the role of CSF1R in tumor microenvironments and immune modulation.
Product Information
Catalog NumA34617
FormulaC23H27N7O3S
Molecular Weight481.57
CAS Number2231259-36-0
SMILESCOC1=C2C(SC(N[C@@H]3[C@H](CCCC3)O)=N2)=CC(OCC4=NC(NC5=CN(N=C5)C)=NC=C4)=C1
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