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Description IDF-11774 is a hypoxia-inducible factor-1 (HIF-1) inhibitor. It reduces the HRE-luciferase activity of HIF-1α (IC50 = 3.65 μM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.14 mL | 135.68 mL | 271.36 mL |
| 0.5 mM | 5.43 mL | 27.14 mL | 54.27 mL |
| 1 mM | 2.71 mL | 13.57 mL | 27.14 mL |
| 5 mM | 0.54 mL | 2.71 mL | 5.43 mL |
*The above data is based on the productmolecular weight 368.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16845 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 368.51 |
| Formula | C23H32N2O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1429054-28-3 |
| Synonyms | IDF11774, IDF 11774 |
| SMILES | O=C(N1CCN(C)CC1)COC2=CC=C(C34C[[email protected]]5C[[email protected]@](C4)([H])C[[email protected]](C5)C3)C=C2 |
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