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Biological Activity
Description IDF-11774 is a hypoxia-inducible factor-1 (HIF-1) inhibitor. It reduces the HRE-luciferase activity of HIF-1α (IC50 = 3.65 μM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.
| In vitro | DMSO | 13 mg/mL (35.27 mM) | |
| Water | Insoluble | ||
| Ethanol | 4 mg/mL (10.85 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.14 mL | 135.68 mL | 271.36 mL |
| 0.5 mM | 5.43 mL | 27.14 mL | 54.27 mL |
| 1 mM | 2.71 mL | 13.57 mL | 27.14 mL |
| 5 mM | 0.54 mL | 2.71 mL | 5.43 mL |
*The above data is based on the productmolecular weight 368.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16845 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1429054-28-3 |
| Formula | C23H32N2O2 |
| M. Wt | 368.51 |
| Purity | >98% |
| Synonyms | IDF11774, IDF 11774 |
| SMILES | O=C(N1CCN(C)CC1)COC2=CC=C(C34C[[email protected]]5C[[email protected]@](C4)([H])C[[email protected]](C5)C3)C=C2 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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