IDF-11774

Name: IDF-11774
Brand: Adooq Bioscience
SKU: A16845
Rating: 5 (288 reviews)

Catalog No.: A16845

HIF-1 inhibitor

Biological Activity Description IDF-11774 is a hypoxia-inducible factor-1 (HIF-1) inhibitor. It reduces the HRE-luciferase activity of HIF-1α (IC50 = 3.65 μM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.

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Grouped product items
Size	Price	Stock
1mg	$50.00	In stock
2mg	$85.00	In stock
5mg	$105.00	In stock
10mg	$190.00	In stock
25mg	$320.00	In stock
50mg	$480.00	In stock
100mg	$705.00	In stock
*10mM 1mL in DMSO**	$85.00	In stock
Bulk Size	Bulk Discount

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Biological Activity

Description	Biological Activity Description IDF-11774 is a hypoxia-inducible factor-1 (HIF-1) inhibitor. It reduces the HRE-luciferase activity of HIF-1α (IC50 = 3.65 μM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.

Product Information

Catalog Num	A16845
Formula	C23H32N2O2
Molecular Weight	368.51
CAS Number	1429054-28-3
SMILES	O=C(N1CCN(C)CC1)COC2=CC=C(C34C[C@H]5C[C@@](C4)([H])C[C@H](C5)C3)C=C2
Synonyms	IDF11774, IDF 11774
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro	DMSO	13 mg/mL (35.27 mM)
	Water	Insoluble
	Ethanol	4 mg/mL (10.85 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.14 mL	135.68 mL	271.36 mL
0.5 mM	5.43 mL	27.14 mL	54.27 mL
1 mM	2.71 mL	13.57 mL	27.14 mL
5 mM	0.54 mL	2.71 mL	5.43 mL

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