IMAB027 (ASP1650) is a monoclonal antibody specifically targeting CLDN6 (Claudin 6), a tight junction membrane protein. CLDN6 is aberrantly expressed in a range of human cancers, particularly in ovarian cancers. This antibody has demonstrated potent anti-tumor activity and can induce apoptosis in CLDN6-positive ovarian and testicular cancer cell lines. IMAB027 is utilized primarily in research focused on the pathological roles of CLDN6 in cancer and the therapeutic potential of targeting this protein in oncology.
IMAB027 (ASP1650) is a monoclonal antibody specifically targeting CLDN6 (Claudin 6), a tight junction membrane protein. CLDN6 is aberrantly expressed in a range of human cancers, particularly in ovarian cancers. This antibody has demonstrated potent anti-tumor activity and can induce apoptosis in CLDN6-positive ovarian and testicular cancer cell lines. IMAB027 is utilized primarily in research focused on the pathological roles of CLDN6 in cancer and the therapeutic potential of targeting this protein in oncology.
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Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
Frequently Asked Questions
What are Biosimilar Antibodies?
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research.
Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
