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Biological Activity
INCB28060, a novel inhibitor of c-MET kinase. INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines.
Targets
| c-Met (Cell-free assay) | ||||
| 0.13 nM |
| In vitro | DMSO | 2 mg/mL (4.84 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.25 mL | 121.24 mL | 242.48 mL |
| 0.5 mM | 4.85 mL | 24.25 mL | 48.5 mL |
| 1 mM | 2.42 mL | 12.12 mL | 24.25 mL |
| 5 mM | 0.48 mL | 2.42 mL | 4.85 mL |
*The above data is based on the productmolecular weight 412.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11132 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1029712-80-8 |
| Formula | C23H17FN6O |
| M. Wt | 412.4 |
| Purity | >98% |
| Synonyms | INCB-28060, INC-280, INC280 |
| SMILES | CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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