JS25 is a selective covalent inhibitor of Bruton's tyrosine kinase (BTK), exhibiting an IC50 value of 5.8 nM through chelation of Tyr551. This compound demonstrates potent anti-proliferative effects on cancer cells, induces apoptosis, and has shown efficacy in promoting tumor regression in murine xenograft models of Burkitt's lymphoma. Notably, JS25 effectively crosses the blood-brain barrier, making it a valuable tool for research in brain-related malignancies.
JS25 is a selective covalent inhibitor of Bruton's tyrosine kinase (BTK), exhibiting an IC50 value of 5.8 nM through chelation of Tyr551. This compound demonstrates potent anti-proliferative effects on cancer cells, induces apoptosis, and has shown efficacy in promoting tumor regression in murine xenograft models of Burkitt's lymphoma. Notably, JS25 effectively crosses the blood-brain barrier, making it a valuable tool for research in brain-related malignancies.
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