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Biological Activity
TE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.28 mL | 96.41 mL | 192.83 mL |
| 0.5 mM | 3.86 mL | 19.28 mL | 38.57 mL |
| 1 mM | 1.93 mL | 9.64 mL | 19.28 mL |
| 5 mM | 0.39 mL | 1.93 mL | 3.86 mL |
*The above data is based on the productmolecular weight 518.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18391 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1255303-54-8 |
| Formula | C30H34N2O6 |
| M. Wt | 518.6 |
| Purity | >98% |
| Synonyms | JTE952. JTE 952 |
| SMILES | O=C(N1CC(C2=CC=C(OCC3=CC=C(C4CC4)C=C3)C(OC)=C2)C1)C5=NC=CC(COC[[email protected]@H](O)CO)=C5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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