Biological Activity
KC7F2 is an inhibitor of HIF-1α protein translation, but not transcription, that suppresses phosphorylation of two key regulators of protein synthesis, eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase (S6K).
Targets
HIF-1α | ||||
20 μM |
In vitro | DMSO | 94 mg/mL (164.8 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 17.53 mL | 87.66 mL | 175.32 mL |
0.5 mM | 3.51 mL | 17.53 mL | 35.06 mL |
1 mM | 1.75 mL | 8.77 mL | 17.53 mL |
5 mM | 0.35 mL | 1.75 mL | 3.51 mL |
*The above data is based on the productmolecular weight 570.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A15359 |
---|---|
Actions | Inhibitor |
CAS No. | 927822-86-4 |
Formula | C16H16Cl4N2O4S4 |
M. Wt | 570.38 |
Solubility | DMSO |
Purity | >98% |
SMILES | C1=CC(=C(C=C1Cl)S(=O)(=O)NCCSSCCNS(=O)(=O)C2=C(C=CC(=C2)Cl)Cl)Cl |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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