KIN-8194 is an orally active dual inhibitor targeting HCK and BTK, exhibiting IC50 values of 0.915 nM and <0.495 nM, respectively. It effectively disrupts growth and integrin-mediated adhesion in BTK inhibitor-resistant mantle cell lymphoma (MCL). KIN-8194 demonstrates the ability to overcome ibrutinib resistance, providing a survival advantage in TMD-8 ABC DLBCL xenograft models, making it a valuable tool for research in hematologic malignancies and therapeutic resistance mechanisms.
KIN-8194 is an orally active dual inhibitor targeting HCK and BTK, exhibiting IC50 values of 0.915 nM and <0.495 nM, respectively. It effectively disrupts growth and integrin-mediated adhesion in BTK inhibitor-resistant mantle cell lymphoma (MCL). KIN-8194 demonstrates the ability to overcome ibrutinib resistance, providing a survival advantage in TMD-8 ABC DLBCL xenograft models, making it a valuable tool for research in hematologic malignancies and therapeutic resistance mechanisms.
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