KRN 633

Catalog No.: A10504

VEGFR Inhibitor

KRN 633

KRN 633 Chemical Structure

CAS NO. 286370-15-8

KRN 633 is a cell-permeable, reversible, ATP-competitive VEGFR kinase inhibitor that inhibits PDGFR-α and c-Kit at higher concentrations only (IC50 = 0.97 μM and 4.33 μM, respectively) and inactive towards 17 other kinases (IC50 ≥ 10 μM).

Availability: In stock

Package Price Qty
5 mg

Regular Price: $80.00

Special Price $64.00

10 mg

Regular Price: $140.00

Special Price $112.00

50 mg

Regular Price: $340.00

Special Price $272.00

100 mg

Regular Price: $540.00

Special Price $432.00

10mM * 1mL in DMSO
$90.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

KRN 633 is a cell-permeable, reversible, ATP-competitive VEGFR kinase inhibitor that inhibits PDGFR-α and c-Kit at higher concentrations only (IC50 = 0.97 μM and 4.33 μM, respectively) and inactive towards 17 other kinases (IC50 ≥ 10 μM).
Targets
Target Value
VEGFR3IC50: 125nM
VEGFR2IC50: 160nM
VEGFR1IC50: 170nM
PDGFRαIC50: 965nM
c-KitIC50: 4330nM
BTKIC50: 9200nM
PDGFRβIC50: 9850nM
Tie-2IC50: 9900nM
In vitro (25°C) DMSO 9 mg/mL (21.58 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.99 mL 119.93 mL 239.87 mL
0.5 mM 4.8 mL 23.99 mL 47.97 mL
1 mM 2.4 mL 11.99 mL 23.99 mL
5 mM 0.48 mL 2.4 mL 4.8 mL

*The above data is based on the productmolecular weight 416.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A10504
Actions Inhibitor
M. Wt 416.9
Formula C20H21ClN4O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 286370-15-8
Synonyms KRN633, KRN-633
SMILES CCCNC(=O)NC1=C(C=C(C=C1)OC2=NC=NC3=CC(=C(C=C32)OC)OC)Cl

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