Total item
Cart Subtotal
$0.00 Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order
Biological Activity
KRN 633 is a cell-permeable, reversible, ATP-competitive VEGFR kinase inhibitor that inhibits PDGFR-α and c-Kit at higher concentrations only (IC50 = 0.97 μM and 4.33 μM, respectively) and inactive towards 17 other kinases (IC50 ≥ 10 μM).
Targets
| Target | Value |
|---|---|
| VEGFR3 | IC50: 125nM |
| VEGFR2 | IC50: 160nM |
| VEGFR1 | IC50: 170nM |
| PDGFRα | IC50: 965nM |
| c-Kit | IC50: 4330nM |
| BTK | IC50: 9200nM |
| PDGFRβ | IC50: 9850nM |
| Tie-2 | IC50: 9900nM |
| In vitro (25°C) | DMSO | 8 mg/mL (19.18 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 0.5% methylcellulose+0.2% Tween 80 | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.99 mL | 119.93 mL | 239.87 mL |
| 0.5 mM | 4.8 mL | 23.99 mL | 47.97 mL |
| 1 mM | 2.4 mL | 11.99 mL | 23.99 mL |
| 5 mM | 0.48 mL | 2.4 mL | 4.8 mL |
*The above data is based on the productmolecular weight 416.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10504 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 286370-15-8 |
| Formula | C20H21ClN4O4 |
| M. Wt | 416.9 |
| Purity | >98% |
| Synonyms | KRN633, KRN-633 |
| SMILES | CCCNC(=O)NC1=C(C=C(C=C1)OC2=NC=NC3=CC(=C(C=C32)OC)OC)Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
Vandetanib (ZD6474)
Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9…
Taxifolin
Taxifolin is found to bind at the ATP-binding site on VEGFR-2 kinase with large value of binding energy and act as type I competitive inhibi…
ZM 323881 hydrochloride
ZM 323881 is a potent and selective inhibitor of the kinase activity of the human vascular endothelial growth factor receptor 2 (VEGFR2/KDR)…
DCC-2618
DCC-2618 is a small molecule inhibitor of c-Kit and PDGFR with IC50s of 6 nM/30 nM/13 nM for c-Kit/PDGFRα/PDGFRβ respectively.
Pazopanib HCl (GW786034)
Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit th…
CP-547632
CP-547632 is a novel, potent vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor
NVP-BAW2881
NVP-BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity …
Regorafenib (BAY 73-4506)
Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an ora…
Keywords:buy KRN 633 | KRN 633 Supplier | purchase | cost | manufacturer | order | distributor | buy 286370-15-8| 286370-15-8 Supplier | purchase 286370-15-8 | 286370-15-8 cost | 286370-15-8 manufacturer | order 286370-15-8 | 286370-15-8 distributor
Adooq Quality Guarantee
We promise all products perform as described.