Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order

KRN 633

Catalog No.: A10504

VEGFR Inhibitor

KRN 633

KRN 633 Chemical Structure

CAS NO. 286370-15-8

KRN 633 is a cell-permeable, reversible, ATP-competitive VEGFR kinase inhibitor that inhibits PDGFR-α and c-Kit at higher concentrations only (IC50 = 0.97 μM and 4.33 μM, respectively) and inactive towards 17 other kinases (IC50 ≥ 10 μM).

Availability: In stock

Package Price Qty
5 mg
$80.00
10 mg
$140.00
50 mg
$340.00
100 mg
$540.00
10mM * 1mL in DMSO
$90.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

KRN 633 is a cell-permeable, reversible, ATP-competitive VEGFR kinase inhibitor that inhibits PDGFR-α and c-Kit at higher concentrations only (IC50 = 0.97 μM and 4.33 μM, respectively) and inactive towards 17 other kinases (IC50 ≥ 10 μM).
Targets
Target Value
VEGFR3IC50: 125nM
VEGFR2IC50: 160nM
VEGFR1IC50: 170nM
PDGFRαIC50: 965nM
c-KitIC50: 4330nM
BTKIC50: 9200nM
PDGFRβIC50: 9850nM
Tie-2IC50: 9900nM
In vitro (25°C) DMSO 8 mg/mL (19.18 mM)
Water Insoluble
Ethanol Insoluble
In vivo 0.5% methylcellulose+0.2% Tween 80 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.99 mL 119.93 mL 239.87 mL
0.5 mM 4.8 mL 23.99 mL 47.97 mL
1 mM 2.4 mL 11.99 mL 23.99 mL
5 mM 0.48 mL 2.4 mL 4.8 mL

*The above data is based on the productmolecular weight 416.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10504
Actions Inhibitor
CAS No. 286370-15-8
Formula C20H21ClN4O4
M. Wt 416.9
Purity >98%
Synonyms KRN633, KRN-633
SMILES CCCNC(=O)NC1=C(C=C(C=C1)OC2=NC=NC3=CC(=C(C=C32)OC)OC)Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
You may also be interested in the following product(s)
Keywords:buy KRN 633 | KRN 633 Supplier | purchase | cost | manufacturer | order | distributor | buy 286370-15-8| 286370-15-8 Supplier | purchase 286370-15-8 | 286370-15-8 cost | 286370-15-8 manufacturer | order 286370-15-8 | 286370-15-8 distributor
Rewards