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LDK378 dihydrochloride

ALK inhibitor

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Catalog No. A15142

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
LDK378 dihydrochloride 5mg A15142-5
€47.50
LDK378 dihydrochloride 10mg A15142-10
€66.50
LDK378 dihydrochloride 50mg A15142-50
€95.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

LDK378 dihydrochloride is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively.

LDK378 dihydrochloride

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Chemical Information

Catalog Num A15142
Actions Inhibitor
M. Wt 594.6
Formula C28H37Cl2N5O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1380575-43-8
Synonyms LDK 378 dihydrochloride, LDK-378 dihydrochloride, Ceritinib dihydrochloride
SMILES CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl.Cl.Cl

Biological Activity

Description
LDK378 dihydrochloride is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.82 mL 84.09 mL 168.18mL
0.5 mM 3.36 mL 16.82 mL 33.64 mL
1 mM 1.68 mL 8.41 mL 16.82 mL
5 mM 0.34 mL 1.68 mL 3.36 mL

*The above data is based on the productmolecular weight 594.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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