LDK378 (Ceritinib) dihydrochloride

Catalog No.: A15142

ALK inhibitor

LDK378 (Ceritinib) dihydrochloride

LDK378 (Ceritinib) dihydrochloride Chemical Structure

CAS NO. 1380575-43-8

LDK378 dihydrochloride is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively.

Availability: In stock

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5 mg
$50.00
10 mg
$70.00
50 mg
$100.00
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Biological Activity

LDK378 dihydrochloride is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.85 mL 79.23 mL 158.45 mL
0.5 mM 3.17 mL 15.85 mL 31.69 mL
1 mM 1.58 mL 7.92 mL 15.85 mL
5 mM 0.32 mL 1.58 mL 3.17 mL

*The above data is based on the productmolecular weight 631.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15142
Actions Inhibitor
CAS No. 1380575-43-8
Formula C28H38Cl3N5O3S
M. Wt 631.1
Purity >98%
Synonyms LDK 378 dihydrochloride, LDK-378 dihydrochloride, Ceritinib dihydrochloride
SMILES CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl.Cl.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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