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Ledadotin

Catalog No.: A41503
Drug-Linker Conjugate for ADC
Ledadotin is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It comprises Auristatin F-hydroxypropylamide, a microtubule inhibitor, linked to a specialized PEG-based linker. This compound is utilized in the synthesis of the ADC Emiltatug ledadotin, making it valuable for targeted cancer therapies and related research applications.
Ledadotin 2669084-60-8 Drug-Linker Conjugate for ADC
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionLedadotin is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It comprises Auristatin F-hydroxypropylamide, a microtubule inhibitor, linked to a specialized PEG-based linker. This compound is utilized in the synthesis of the ADC Emiltatug ledadotin, making it valuable for targeted cancer therapies and related research applications.
Product Information
Catalog NumA41503
FormulaC294H494N52O100
Molecular Weight6357.36
CAS Number2669084-60-8
SMILESO=C(NCCC(NCC(NCC(NCC(NCC(N[C@H](C(NCCOCCOCCOCCOCCOCCOCCOCCOC)=O)COC(NCCC(N[C@H](C(O)=O)CCC(N[C@H](C(OCCCNC([C@@H](CC1=CC=CC=C1)NC([C@H]([C@H](OC)[C@H]2CCCN2C(C[C@@H]([C@@H]([C@@H](CC)C)N(C([C@@H](C(C)C)NC([C@@H](C(C)C)N(C)C)=O)=O)C)OC)=O)C)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)CCOCC(COCCC(NCCC(NCC(NCC(NCC(NCC(N[C@H](C(NCCOCCOCCOCCOCCOCCOCCOCCOC)=O)COC(NCCC(N[C@H](C(O)=O)CCC(N[C@H](C(OCCCNC([C@@H](CC3=CC=CC=C3)NC([C@H]([C@H](OC)[C@H]4CCCN4C(C[C@@H]([C@@H]([C@@H](CC)C)N(C([C@@H](C(C)C)NC([C@@H](C(C)C)N(C)C)=O)=O)C)OC)=O)C)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)(COCCC(NCCC(NCC(NCC(NCC(NCC(N[C@H](C(NCCOCCOCCOCCOCCOCCOCCOCCOC)=O)COC(NCCC(N[C@H](C(O)=O)CCC(N[C@H](C(OCCCNC([C@@H](CC5=CC=CC=C5)NC([C@H]([C@H](OC)[C@H]6CCCN6C(C[C@@H]([C@@H]([C@@H](CC)C)N(C([C@@H](C(C)C)NC([C@@H](C(C)C)N(C)C)=O)=O)C)OC)=O)C)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC(CNC(CCC(NCCOCCOCCNC(OC[C@H]7[C@]8(CCC#CCC[C@]87[H])[H])=O)=O)=O)=O
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC