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LFM-A13 is a potent and selective inhibitor of Btk with IC50 of 17.2 uM; also inhibits PLK3 with IC50 of 7.2 uM.
Targets
| BTK | ||||
| 2.5 μM |
| In vitro | DMSO | Warmed: 67 mg/mL (186.11 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.78 mL | 138.89 mL | 277.78 mL |
| 0.5 mM | 5.56 mL | 27.78 mL | 55.56 mL |
| 1 mM | 2.78 mL | 13.89 mL | 27.78 mL |
| 5 mM | 0.56 mL | 2.78 mL | 5.56 mL |
*The above data is based on the productmolecular weight 360. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16261 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 244240-24-2 |
| Formula | C11H8Br2N2O2 |
| M. Wt | 360 |
| Purity | >98% |
| Synonyms | LFM A13 |
| SMILES | C/C(O)=C(/C(O)=N/C1=C(Br)C=CC(Br)=C1)C#N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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