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LOXO-101 (ARRY-470, Larotrectinib)

TRK inhibitor

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Catalog No. A15974

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
LOXO-101 (ARRY-470) 5mg A15974-5
$90.00
LOXO-101 (ARRY-470) 10mg A15974-10
$140.00
LOXO-101 (ARRY-470) 50mg A15974-50
$420.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

LOXO-101 is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC.

LOXO-101 (ARRY-470, Larotrectinib)

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Chemical Information

Catalog Num A15974
Actions Inhibitor
M. Wt 428.44
Formula C21H22F2N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1223403-58-4
Synonyms LOXO 101, LOXO101, ARRY470, ARRY 470
SMILES O=C(N1CC[[email protected]@H](C1)O)NC2=C3N=C(N4CCC[[email protected]@H]4C5=CC(F)=CC=C5F)C=CN3N=C2

Biological Activity

Description
LOXO-101 is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.34 mL 116.7 mL 233.4mL
0.5 mM 4.67 mL 23.34 mL 46.68 mL
1 mM 2.33 mL 11.67 mL 23.34 mL
5 mM 0.47 mL 2.33 mL 4.67 mL

*The above data is based on the productmolecular weight 428.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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