LOXO-101 (ARRY-470, Larotrectinib)

Catalog No.: A15974

TRK inhibitor

LOXO-101 (ARRY-470, Larotrectinib)

LOXO-101 (ARRY-470, Larotrectinib) Chemical Structure

CAS NO. 1223403-58-4

LOXO-101 is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$140.00
50 mg
$420.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

LOXO-101 is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.34 mL 116.7 mL 233.4 mL
0.5 mM 4.67 mL 23.34 mL 46.68 mL
1 mM 2.33 mL 11.67 mL 23.34 mL
5 mM 0.47 mL 2.33 mL 4.67 mL

*The above data is based on the productmolecular weight 428.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A15974
Actions Inhibitor
M. Wt 428.44
Formula C21H22F2N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1223403-58-4
Synonyms LOXO 101, LOXO101, ARRY470, ARRY 470
SMILES O=C(N1CC[[email protected]@H](C1)O)NC2=C3N=C(N4CCC[[email protected]@H]4C5=CC(F)=CC=C5F)C=CN3N=C2

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