LOXO-101 (ARRY-470, Larotrectinib)

Catalog No.: A15974

TRK inhibitor

LOXO-101 (ARRY-470, Larotrectinib)

LOXO-101 (ARRY-470, Larotrectinib) Chemical Structure

CAS NO. 1223403-58-4

LOXO-101 is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC.

Availability: In stock

Package Price Qty
5 mg
$75.00
10 mg
$140.00
50 mg
$420.00
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Biological Activity

LOXO-101 is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC.
In vitro DMSO 85 mg/mL (198.39 mM)
Water Insoluble
Ethanol 85 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.34 mL 116.7 mL 233.4 mL
0.5 mM 4.67 mL 23.34 mL 46.68 mL
1 mM 2.33 mL 11.67 mL 23.34 mL
5 mM 0.47 mL 2.33 mL 4.67 mL

*The above data is based on the productmolecular weight 428.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15974
Actions Inhibitor
CAS No. 1223403-58-4
Formula C21H22F2N6O2
M. Wt 428.44
Purity >98%
Synonyms LOXO 101, LOXO101, ARRY470, ARRY 470
SMILES O=C(N1CC[[email protected]@H](C1)O)NC2=C3N=C(N4CCC[[email protected]@H]4C5=CC(F)=CC=C5F)C=CN3N=C2
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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