LW1564 is a potent inhibitor of HIF-1α, demonstrating an IC50 of 1.2 µM in HepG2 cells. It disrupts mitochondrial respiration, decreases ATP production, promotes HIF-1α degradation, and inhibits the proliferation of diverse cancer cell types with a GI50 ranging from 0.4 to 4.6 μM. Additionally, LW1564 activates the AMPK signaling pathway while inhibiting lipid synthesis, showcasing its potential for research in cancer biology. Its antitumor efficacy has also been validated in a HepG2 xenograft mouse model.
LW1564 is a potent inhibitor of HIF-1α, demonstrating an IC50 of 1.2 µM in HepG2 cells. It disrupts mitochondrial respiration, decreases ATP production, promotes HIF-1α degradation, and inhibits the proliferation of diverse cancer cell types with a GI50 ranging from 0.4 to 4.6 μM. Additionally, LW1564 activates the AMPK signaling pathway while inhibiting lipid synthesis, showcasing its potential for research in cancer biology. Its antitumor efficacy has also been validated in a HepG2 xenograft mouse model.
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