LY 2874455

Catalog No.: A11244

FGFR/VEGFR2 inhibitor

LY 2874455

LY 2874455 Chemical Structure

CAS NO. 1254473-64-7

LY2874455 is a novel and potent FGFR/VEGFR Inhibitor.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $120.00

Special Price $96.00

10 mg

Regular Price: $200.00

Special Price $160.00

25 mg

Regular Price: $360.00

Special Price $288.00

50 mg

Regular Price: $680.00

Special Price $544.00

10mM * 1mL in DMSO

Regular Price: $140.00

Special Price $112.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

LY2874455 is a novel and potent FGFR/VEGFR Inhibitor.
Targets
FGFR2 FGFR1 FGFR4 FGFR3 VEGFR2
2.6 nM2.8 nM6 nM6.4 nM7 nM
In vitro (25°C) DMSO 86 mg/mL (193.55 mM)
Water Insoluble
Ethanol Warmed: 56 mg/mL (126.03 mM)
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.51 mL 112.53 mL 225.07 mL
0.5 mM 4.5 mL 22.51 mL 45.01 mL
1 mM 2.25 mL 11.25 mL 22.51 mL
5 mM 0.45 mL 2.25 mL 4.5 mL

*The above data is based on the productmolecular weight 444.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11244
Actions Inhibitor
CAS No. 1254473-64-7
Formula C21H19Cl2N5O2
M. Wt 444.31
Purity >98%
Synonyms LY-2874455, LY2874455
SMILES C[[email protected]](C1=C(C=NC=C1Cl)Cl)OC2=CC3=C(C=C2)NN=C3/C=C/C4=CN(N=C4)CCO
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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