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Mal((3S,3aR,6S,6aR)-Hexahydrofuro3,2-bfuran-3,6-diamine-PEG12)-β-Glu-PAB-Exatecan

Catalog No.: A41386
Drug-Linker Conjugate for ADC
Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB-Exatecan is a sophisticated drug-linker conjugate that targets DNA Topoisomerase I with the potent inhibitor Exatecan. This compound is designed for use in antibody-drug conjugates (ADCs), providing enhanced specificity and efficacy in cancer therapy. Its unique linker structure facilitates the stable attachment of therapeutic agents to antibodies, improving targeting and reducing systemic toxicity in research applications.
Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB-Exatecan 3059991-66-8 Drug-Linker Conjugate for ADC
Grouped product items
Size Price Stock Qty
1mg
$615.00
In stock
5mg
$1,585.00
In stock
10mg
$2,605.00
In stock
25mg
$5,145.00
In stock
50mg
$8,035.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB-Exatecan is a sophisticated drug-linker conjugate that targets DNA Topoisomerase I with the potent inhibitor Exatecan. This compound is designed for use in antibody-drug conjugates (ADCs), providing enhanced specificity and efficacy in cancer therapy. Its unique linker structure facilitates the stable attachment of therapeutic agents to antibodies, improving targeting and reducing systemic toxicity in research applications.
Product Information
Catalog NumA41386
FormulaC87H118FN9O34
Molecular Weight1852.91
CAS Number3059991-66-8
SMILESO=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5NC(OCC7=CC=C(O[C@@H]8O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]8O)C(CNC(CCNC([C@@H](NC(CCN9C(C=CC9=O)=O)=O)CCCC(N[C@@H]%10[C@@H](OC[C@@H]%11NC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)[C@@H]%11OC%10)=O)=O)=O)=C7)=O)C(C)=C(F)C=C6N=C4C3=C2)=O
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC