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Mal-Cyclobutane-1,1-dicarboxamide-Cit-PAB-MMAE

Catalog No.: A41522
Drug-Linker Conjugates for ADC
Mal-Cyclobutane-1,1-dicarboxamide-Cit-PAB-MMAE is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound consists of the payload MMAE and the linker Mal-Cyclobutane-1,1-dicarboxamide-Cit-PAB, enabling effective targeted delivery of cytotoxic agents to cancer cells. The conjugate functions by utilizing the specificity of antibodies to selectively deliver the cytotoxic MMAE, facilitating enhanced therapeutic efficacy in oncological research.
Mal-Cyclobutane-1,1-dicarboxamide-Cit-PAB-MMAE 2226490-67-9 Drug-Linker Conjugates for ADC
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMal-Cyclobutane-1,1-dicarboxamide-Cit-PAB-MMAE is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound consists of the payload MMAE and the linker Mal-Cyclobutane-1,1-dicarboxamide-Cit-PAB, enabling effective targeted delivery of cytotoxic agents to cancer cells. The conjugate functions by utilizing the specificity of antibodies to selectively deliver the cytotoxic MMAE, facilitating enhanced therapeutic efficacy in oncological research.
Product Information
Catalog NumA41522
FormulaC68H103N11O15
Molecular Weight1314.61
CAS Number2226490-67-9
SMILESO=C(N1[C@](CCC1)([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC(C=C3)=CC=C3NC([C@H](CCCNC(N)=O)NC(C4(CCC4)C(NCCCCCN5C(C=CC5=O)=O)=O)=O)=O)=O)=O)=O
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC