Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA

Catalog No.: A41485
Drug-Linker Conjugate for ADC
Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This reagent facilitates targeted delivery of the potent antitumor antibiotic Duocarmycin SA through its unique linker structure, Mal-PEG4-VC-PAB-DMEA-Seco. Its primary mechanism involves the selective release of the cytotoxic agent upon cellular internalization, thereby enhancing therapeutic efficacy while minimizing off-target effects. This product is suitable for cancer research focused on developing and optimizing ADCs for improved clinical outcomes.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
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Nature volume 610, pages540-546 (2022)
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Nature volume 574, pages268-272 (2019)
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Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
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Biological Activity
DescriptionMal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This reagent facilitates targeted delivery of the potent antitumor antibiotic Duocarmycin SA through its unique linker structure, Mal-PEG4-VC-PAB-DMEA-Seco. Its primary mechanism involves the selective release of the cytotoxic agent upon cellular internalization, thereby enhancing therapeutic efficacy while minimizing off-target effects. This product is suitable for cancer research focused on developing and optimizing ADCs for improved clinical outcomes.
Product Information
Catalog NumA41485
FormulaC67H87ClN12O21
Molecular Weight1431.93
CAS Number2259318-49-3
SMILESClC[C@H]1C2=C(C=C(OC(N(C)CCN(C)C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCNC(CCN4C(C=CC4=O)=O)=O)=O)=O)=O)C=C3)=O)=O)C5=C2C=C(C(OC)=O)N5)N(C(C6=CC7=CC(OC)=C(OC)C(OC)=C7N6)=O)C1
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