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Mal-PEG8-Phe-Lys-PAB-Exatecan

Catalog No.: A41517
Drug-Linker Conjugate for ADC
Mal-PEG8-Phe-Lys-PAB-Exatecan is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound features a degradable linker composed of Mal-PEG8-Phe-Lys-PAB, covalently linked to the potent cytotoxic agent Exatecan. It is utilized in research focusing on targeted cancer therapies, enabling the effective delivery of cytotoxic agents to cancer cells while minimizing off-target effects.
Mal-PEG8-Phe-Lys-PAB-Exatecan 2679821-44-2 Drug-Linker Conjugate for ADC
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMal-PEG8-Phe-Lys-PAB-Exatecan is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound features a degradable linker composed of Mal-PEG8-Phe-Lys-PAB, covalently linked to the potent cytotoxic agent Exatecan. It is utilized in research focusing on targeted cancer therapies, enabling the effective delivery of cytotoxic agents to cancer cells while minimizing off-target effects.
Product Information
Catalog NumA41517
FormulaC73H92FN9O20
Molecular Weight1434.56
CAS Number2679821-44-2
SMILESO=C(C=CC1=O)N1CCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCCN)C(NC(C=C3)=CC=C3COC(N[C@@H]4C5=C6C(C(N7C6)=CC([C@](O)(C(OC8)=O)CC)=C8C7=O)=NC9=CC(F)=C(C)C(CC4)=C95)=O)=O)=O)=O)=O
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC