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Mal-va-mac-SN38

Catalog No.: A41433
Drug-Linker Conjugates for ADC
Mal-va-mac-SN38 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, incorporating the potent cytotoxin SN-38 linked via a stable linker. This compound exhibits rapid and covalent binding to endogenous albumin in vivo, leading to the formation of HSA-va-mac-SN38. Demonstrating remarkable stability in human plasma, Mal-va-mac-SN38 has shown significant anti-tumor and anti-metastasis effects, providing a valuable tool for cancer research and therapeutic development.
Mal-va-mac-SN38 2778229-31-3 Drug-Linker Conjugates for ADC
Grouped product items
Size Price Stock Qty
1mg
$375.00
In stock
5mg
$970.00
In stock
10mg
$1,595.00
In stock
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Free Delivery on orders over $500
Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMal-va-mac-SN38 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, incorporating the potent cytotoxin SN-38 linked via a stable linker. This compound exhibits rapid and covalent binding to endogenous albumin in vivo, leading to the formation of HSA-va-mac-SN38. Demonstrating remarkable stability in human plasma, Mal-va-mac-SN38 has shown significant anti-tumor and anti-metastasis effects, providing a valuable tool for cancer research and therapeutic development.
Product Information
Catalog NumA41433
FormulaC52H61N7O14S
Molecular Weight1040.14
CAS Number2778229-31-3
SMILESO=C(N(COC1=CC=C(N=C(C(N2C3)=CC([C@@](O)(CC)C(OC4)=O)=C4C2=O)C3=C5CC)C5=C1)CCS(=O)(C)=O)OCC6=CC=C(NC([C@@H](NC([C@H](C(C)C)NC(CCCCCN7C(C=CC7=O)=O)=O)=O)C)=O)C=C6
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC