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Mal-Val-Ala-amide-(3)PEA-PNU-159682

Catalog No.: A41605
Drug-Linker Conjugates for ADC
Mal-Val-Ala-amide-(3)PEA-PNU-159682 is a drug-linker conjugate designed for targeted antibody-drug conjugate (ADC) applications. This compound features an ADC linker, Mal-Val-Ala-amide-(3)PEA, which is covalently bonded to the cytotoxic agent PNU-159682, exhibiting notable anti-tumor activity. It is suitable for research into cancer therapies, utilizing precise delivery mechanisms to enhance therapeutic efficacy while minimizing off-target effects.
Mal-Val-Ala-amide-(3)PEA-PNU-159682 2682939-56-4 Drug-Linker Conjugates for ADC
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMal-Val-Ala-amide-(3)PEA-PNU-159682 is a drug-linker conjugate designed for targeted antibody-drug conjugate (ADC) applications. This compound features an ADC linker, Mal-Val-Ala-amide-(3)PEA, which is covalently bonded to the cytotoxic agent PNU-159682, exhibiting notable anti-tumor activity. It is suitable for research into cancer therapies, utilizing precise delivery mechanisms to enhance therapeutic efficacy while minimizing off-target effects.
Product Information
Catalog NumA41605
FormulaC53H60N6O17
Molecular Weight1053.07
CAS Number2682939-56-4
SMILESOC1=C(C(C2=CC=CC(OC)=C2C3=O)=O)C3=C(O)C4=C1C[C@](C(NCCC5=CC(NC([C@H](C)NC([C@H](C(C)C)NC(CN6C(C=CC6=O)=O)=O)=O)=O)=CC=C5)=O)(O)C[C@@H]4O[C@H]7C[C@]8([H])N9[C@]([C@H](OCC9)OC)([H])O[C@]8([H])[C@@H](O7)C
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC