Mal-Val-Ala-PAB-N(SO2Me)-Exatecan is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound combines the cytotoxic agent Exatecan with a specialized linker, enabling targeted delivery to cancer cells. Mal-Val-Ala-PAB-N(SO2Me)-Exatecan is utilized in the synthesis of FZ-AD005, an ADC targeting delta-like ligand 3 (DLL3) with a binding affinity of 58.3 pM, which demonstrates significant antitumor activity against small cell lung cancer (SCLC).
Mal-Val-Ala-PAB-N(SO2Me)-Exatecan is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound combines the cytotoxic agent Exatecan with a specialized linker, enabling targeted delivery to cancer cells. Mal-Val-Ala-PAB-N(SO2Me)-Exatecan is utilized in the synthesis of FZ-AD005, an ADC targeting delta-like ligand 3 (DLL3) with a binding affinity of 58.3 pM, which demonstrates significant antitumor activity against small cell lung cancer (SCLC).
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