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Mal-VC-PAB-EDA-N-Ac-Calicheamicin

Catalog No.: A41591
Drug-Linker Conjugate for ADC
Mal-VC-PAB-EDA-N-Ac-Calicheamicin is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This molecule features the potent antitumor agent Calicheamicin, linked via a novel chemical moiety to facilitate selective delivery to tumor cells. It serves as a critical component in the synthesis of ADCs, such as PF-06647263, and is essential for advancing research in targeted cancer therapies.
Mal-VC-PAB-EDA-N-Ac-Calicheamicin 2028299-61-6 Drug-Linker Conjugate for ADC
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMal-VC-PAB-EDA-N-Ac-Calicheamicin is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This molecule features the potent antitumor agent Calicheamicin, linked via a novel chemical moiety to facilitate selective delivery to tumor cells. It serves as a critical component in the synthesis of ADCs, such as PF-06647263, and is essential for advancing research in targeted cancer therapies.
Product Information
Catalog NumA41591
FormulaC93H128IN11O31S3
Molecular Weight2119.17
CAS Number2028299-61-6
SMILESC[C@H]1O[C@H](C[C@@H]([C@@H]1SC(C(C(C)=C(C(O[C@@H]2O[C@H]([C@@H]([C@H]([C@H]2O)OC)O)C)=C3OC)I)=C3OC)=O)O)ON[C@@H]4[C@@H](C)OC(O[C@@H](C#C/C=C\C#C[C@@]/5(O)CC6=O)C(C5=C/CSSC(C)(CCC(NCCNC(OCC7=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN8C(C=CC8=O)=O)=O)=O)=O)C=C7)=O)=O)C)=C6NC(OC)=O)[C@H](O[C@H]9C[C@H](OC)[C@@H](N(C(C)=O)CC)CO9)[C@H]4O
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC