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Biological Activity
MC-GGFG-DX8951 is a drug-linker conjugate for ADC with antitumor activity by using DX8951 (a DNA topoisomerase I inhibitor), linked via the protease cleavable MC-GGFG linker.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 10.56 mL | 52.8 mL | 105.6 mL |
| 0.5 mM | 2.11 mL | 10.56 mL | 21.12 mL |
| 1 mM | 1.06 mL | 5.28 mL | 10.56 mL |
| 5 mM | 0.21 mL | 1.06 mL | 2.11 mL |
*The above data is based on the productmolecular weight 946.99. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18781 |
|---|---|
| CAS No. | 1600418-29-8 |
| Formula | C49H51FN8O11 |
| M. Wt | 946.99 |
| Purity | >98% |
| Synonyms | MC-GGFG-DX8951; MC-GGFG-DX-8951; MC-GGFG-DX 8951; MC-GGFG-DX. |
| SMILES | O=C1[[email protected]](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[[email protected]@H]5NC(CNC([[email protected]](CC7=CC=CC=C7)NC(CNC(CNC(CCCCCN8C(C=CC8=O)=O)=O)=O)=O)=O)=O)C(C)=C(F)C=C6N=C4C3=C2)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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