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Mc-Lys(PEG12)-Cap-Ala-Ala-PABC-exatecan

Catalog No.: A41511
Drug-Linker Conjugates for ADC
Mc-Lys(PEG12)-Cap-Ala-Ala-PABC-exatecan is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound features a unique ADC linker (Mc-Lys(PEG12)-Cap-Ala-Ala-PABC) combined with the potent DNA topoisomerase I inhibitor, Exatecan. It is particularly relevant for the development of targeted therapies against HER2-positive breast cancer, facilitating the selective delivery of cytotoxic agents to tumor cells while minimizing off-target effects.
Mc-Lys(PEG12)-Cap-Ala-Ala-PABC-exatecan 3067680-81-0 Drug-Linker Conjugates for ADC
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMc-Lys(PEG12)-Cap-Ala-Ala-PABC-exatecan is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound features a unique ADC linker (Mc-Lys(PEG12)-Cap-Ala-Ala-PABC) combined with the potent DNA topoisomerase I inhibitor, Exatecan. It is particularly relevant for the development of targeted therapies against HER2-positive breast cancer, facilitating the selective delivery of cytotoxic agents to tumor cells while minimizing off-target effects.
Product Information
Catalog NumA41511
FormulaC86H123FN10O26
Molecular Weight1731.95
CAS Number3067680-81-0
SMILESCC[C@]1(C(OCC2=C1C=C3C4=NC5=CC(F)=C(C6=C5C([C@H](CC6)NC(OCC7=CC=C(C=C7)NC([C@@H](NC([C@@H](NC(CCCCCNC([C@@H](NC(CCCCCN8C(C=CC8=O)=O)=O)CCCCNC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)=O)C)=O)C)=O)=O)=C4CN3C2=O)C)=O)O
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC