MerTK/Axl-IN-1 is a highly selective dual inhibitor targeting MerTK and Axl receptors, demonstrating potent inhibitory activity with IC50 values of 4.2 nM and 8.8 nM in Ba/F3 cells, and 0.2 nM and 0.9 nM in HTRF assays. This compound effectively inhibits phosphorylated MerTK (pMerTK) in vivo, indicating its utility in biological research. With a prolonged half-life and favorable oral bioavailability, MerTK/Axl-IN-1 is suitable for studies in cancer biology and therapeutic development aimed at disruptions in MerTK and Axl signaling pathways.
MerTK/Axl-IN-1 is a highly selective dual inhibitor targeting MerTK and Axl receptors, demonstrating potent inhibitory activity with IC50 values of 4.2 nM and 8.8 nM in Ba/F3 cells, and 0.2 nM and 0.9 nM in HTRF assays. This compound effectively inhibits phosphorylated MerTK (pMerTK) in vivo, indicating its utility in biological research. With a prolonged half-life and favorable oral bioavailability, MerTK/Axl-IN-1 is suitable for studies in cancer biology and therapeutic development aimed at disruptions in MerTK and Axl signaling pathways.
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