MGCD-265 (Glesatinib)

Catalog No.: A10587

c-Met inhibitor

MGCD-265 (Glesatinib) Chemical Structure

CAS NO. 875337-44-3

MGCD265 is a multitargeted tyrosine kinase inhibitor that binds to and inhibits the phosphorylation of several RTKs, including the c-Met receptor (HGFR); the Tek/Tie-2 receptor; VEGFR types 1, 2, and 3; and MST1R.

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$220.00
50 mg
$650.00
100 mg
$980.00
10mM * 1mL in DMSO
$214.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

MGCD265 is a multitargeted tyrosine kinase inhibitor that binds to and inhibits the phosphorylation of several RTKs, including the c-Met receptor (HGFR); the Tek/Tie-2 receptor; VEGFR types 1, 2, and 3; and MST1R.
Targets
Target Value
MetIC50: 1nM
RONIC50: 2nM
VEGFR1IC50: 3nM
VEGFR2IC50: 3nM
VEGFR3IC50: 4nM
Tie-2IC50: 7nM
In vitro DMSO 104 mg/mL (200.92 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.32 mL 96.6 mL 193.2 mL
0.5 mM 3.86 mL 19.32 mL 38.64 mL
1 mM 1.93 mL 9.66 mL 19.32 mL
5 mM 0.39 mL 1.93 mL 3.86 mL

*The above data is based on the productmolecular weight 517.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10587
Actions Inhibitor
M. Wt 517.6
Formula C26H20FN5O2S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 875337-44-3
Synonyms MGCD265
SMILES CN1C=C(N=C1)C2=CC3=NC=CC(=C3S2)OC4=C(C=C(C=C4)NC(=S)NC(=O)CC5=CC=CC=C5)F

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