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Biological Activity
MGCD265 is a multitargeted tyrosine kinase inhibitor that binds to and inhibits the phosphorylation of several RTKs, including the c-Met receptor (HGFR); the Tek/Tie-2 receptor; VEGFR types 1, 2, and 3; and MST1R.
Targets
Target | Value |
---|---|
Met | IC50: 1nM |
RON | IC50: 2nM |
VEGFR1 | IC50: 3nM |
VEGFR2 | IC50: 3nM |
VEGFR3 | IC50: 4nM |
Tie-2 | IC50: 7nM |
In vitro | DMSO | 99 mg/mL (191.26 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 19.32 mL | 96.6 mL | 193.2 mL |
0.5 mM | 3.86 mL | 19.32 mL | 38.64 mL |
1 mM | 1.93 mL | 9.66 mL | 19.32 mL |
5 mM | 0.39 mL | 1.93 mL | 3.86 mL |
*The above data is based on the productmolecular weight 517.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10587 |
---|---|
Actions | Inhibitor |
CAS No. | 875337-44-3 |
Formula | C26H20FN5O2S2 |
M. Wt | 517.6 |
Purity | >98% |
Synonyms | MGCD265 |
SMILES | CN1C=C(N=C1)C2=CC3=NC=CC(=C3S2)OC4=C(C=C(C=C4)NC(=S)NC(=O)CC5=CC=CC=C5)F |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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