Motesanib Diphosphate (AMG-706)

Catalog No.: A10608

VEGFR inhibitor

Motesanib Diphosphate (AMG-706)

Motesanib Diphosphate (AMG-706) Chemical Structure

CAS NO. 857876-30-3

Motesanib, also known as AMG-706, is an orally administered multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors, and Kit receptors.

Availability: In stock

Package Price Qty
5 mg
$30.00
10 mg
$50.00
50 mg
$160.00
100 mg
$280.00
10mM * 1mL in DMSO
$50.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Motesanib, also known as AMG-706, is an orally administered multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors, and Kit receptors.
Targets
Target Value
VEGFR1IC50: 2nM
VEGFR2IC50: 3nM
VEGFR2/Flk1IC50: 6nM
VEGFR3IC50: 6nM
KitIC50: 8nM
RETIC50: 59nM
PDGFRIC50: 84nM
FGFRIC50: >2.8μM
EGFRIC50: >3μM
SrcIC50: >3μM
p38IC50: >3μM
In vitro (25°C) DMSO 100 mg/mL heating (175.61 mM)
Water 19 mg/mL heating (33.36 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.56 mL 87.81 mL 175.62 mL
0.5 mM 3.51 mL 17.56 mL 35.12 mL
1 mM 1.76 mL 8.78 mL 17.56 mL
5 mM 0.35 mL 1.76 mL 3.51 mL

*The above data is based on the productmolecular weight 569.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10608
Actions Inhibitor
M. Wt 569.4
Formula C22H23N5O.2H3PO4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 857876-30-3
Synonyms AMG-706
SMILES CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C.OP(=O)(O)O.OP(=O)(O)O

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