Motesanib Diphosphate (AMG-706)

Catalog No.: A10608
VEGFR inhibitor
Motesanib, also known as AMG-706, is an orally administered multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors, and Kit receptors.
Grouped product items
Product Name Price Stock Qty
Motesanib Diphosphate 5mg
$30.00
In stock
Motesanib Diphosphate 10mg
$50.00
In stock
Motesanib Diphosphate 50mg
$160.00
In stock
Motesanib Diphosphate 100mg
$280.00
In stock
Motesanib Diphosphate 10mM * 1mL in DMSO
$50.00
In stock
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Biological Activity
Discription Motesanib, also known as AMG-706, is an orally administered multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors, and Kit receptors.
Targets
Target Value
Product Information
Catalog Num A10608
Formula C22H23N5O.2H3PO4
Molecular Weight 569.4
CAS Number 857876-30-3
SMILES CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C.OP(=O)(O)O.OP(=O)(O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO Warmed: 88 mg/mL (154.54 mM)
Water Warmed: 17 mg/mL (29.85 mM)
Ethanol Insoluble
In vivo Saline 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.56 mL 87.81 mL 175.62 mL
0.5 mM 3.51 mL 17.56 mL 35.12 mL
1 mM 1.76 mL 8.78 mL 17.56 mL
5 mM 0.35 mL 1.76 mL 3.51 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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