mp-dLAE-PABC-MMAE

Catalog No.: A41469
Drug-Linker Conjugate for ADC
mp-dLAE-PABC-MMAE is a drug-linker conjugate designed for use in antibody-drug conjugates (ADCs). This compound incorporates Monomethyl auristatin E, a potent tubulin inhibitor that disrupts microtubule dynamics, leading to cell cycle arrest and apoptosis in target cells. It is particularly valuable in cancer research and therapeutic applications, enabling the targeted delivery of cytotoxic agents to enhance treatment efficacy while minimizing off-target effects.
Grouped product items
Size Price Stock Qty
1mg
$350.00
In stock
5mg
$895.00
In stock
10mg
$1,470.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Descriptionmp-dLAE-PABC-MMAE is a drug-linker conjugate designed for use in antibody-drug conjugates (ADCs). This compound incorporates Monomethyl auristatin E, a potent tubulin inhibitor that disrupts microtubule dynamics, leading to cell cycle arrest and apoptosis in target cells. It is particularly valuable in cancer research and therapeutic applications, enabling the targeted delivery of cytotoxic agents to enhance treatment efficacy while minimizing off-target effects.
Product Information
Catalog NumA41469
FormulaC68H102N10O17
Molecular Weight1331.59
CAS Number2625616-44-4
SMILESO=C(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N([C@H]([C@@H](CC(N1[C@H]([C@H](OC)[C@H](C(N[C@@H]([C@@H](O)C2=CC=CC=C2)C)=O)C)CCC1)=O)OC)[C@@H](C)CC)C)=O)=O)OCC3=CC=C(NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@@H](CC(C)C)NC(CCN4C(C=CC4=O)=O)=O)=O)=O)=O)C=C3
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