N-MeVal-Val-Dil-Dap-2-(pyridin-3-yl)ethanamine

Catalog No.: A41128
ADC Payload
N-MeVal-Val-Dil-Dap-2-(pyridin-3-yl)ethanamine functions as a tubulin polymerization inhibitor and serves as an effective antibody-drug conjugate (ADC) payload. This compound disrupts microtubule dynamics, which can lead to cancer cell apoptosis. Its application in ADC development is valuable for targeted cancer therapies, enhancing the efficacy of specific antibodies against tumor cells.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionN-MeVal-Val-Dil-Dap-2-(pyridin-3-yl)ethanamine functions as a tubulin polymerization inhibitor and serves as an effective antibody-drug conjugate (ADC) payload. This compound disrupts microtubule dynamics, which can lead to cancer cell apoptosis. Its application in ADC development is valuable for targeted cancer therapies, enhancing the efficacy of specific antibodies against tumor cells.
Product Information
Catalog NumA41128
FormulaC37H64N6O6
Molecular Weight688.94
CAS Number1448364-29-1
SMILESCC(C)[C@@H](C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@H](CC)C)[C@H](OC)CC(N1[C@H]([C@H](OC)[C@@H](C)C(NCCC2=CN=CC=C2)=O)CCC1)=O)=O)=O)NC
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